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For people who want to lose weight but aren’t ready for surgery, there are several effective non-surgical options to consider. Two of the most discussed are the Allurion Gastric Balloon and Ozempic injections. While both are effective alternatives to traditional surgery, they represent fundamentally different approaches. This comprehensive guide breaks down how they work, their results, and risks, providing the clarity you need before making your decision.

Gastric Balloon vs Ozempic Overview

The Allurion Gastric Balloon

The Allurion Gastric Balloon is a non-surgical, temporary medical device designed to help you kickstart your weight loss journey. What sets it apart from traditional gastric balloons is its remarkable simplicity; it requires no endoscopy, sedation, or surgery for placement or removal.

During a brief 15-minute procedure, a swallowable capsule containing the deflated balloon is placed in your stomach. Once confirmed positionally via X-ray, it’s filled with approximately 550ml of liquid, occupying space in your stomach which makes you feel fuller and eat less. The balloon then self-empties and is naturally passed after approximately 16 weeks.

Ozempic Injections

Ozempic is an injectable prescription medication primarily used for type 2 diabetes that has gained widespread use for weight loss. It belongs to a class of drugs called GLP-1 receptor agonists. It works by mimicking a hormone that targets areas in the brain responsible for reducing appetite and increasing feelings of fullness. It also slows down how quickly the stomach empties. Unlike the gastric balloon, Ozempic is not a temporary aid, it is a chronic medication that requires ongoing, often lifelong, use to maintain its effects.

Gastric Balloon vs Ozempic Comparison

Effectiveness & Results

The Allurion Gastric Balloon delivers rapid, significant weight loss results within a defined timeframe, helping patients achieve approximately 10-15% total body weight loss over just four months. These results usually continue after the balloon’s removal because patients develop lasting habits during the treatment period.

Ozempic produces more gradual weight loss outcomes, typically reaching 12-15% total body weight reduction over 12-16 months of continuous use. While effective, these results are directly tied to ongoing medication use, as discontinuing treatment usually leads to weight regain. 

Side Effects & Possible Complications

With the Allurion Balloon, patients typically experience a predictable adjustment period during the first week, including nausea, cramping, and reflux as the body adapts. While rare, there are other risks such as gastric ulcers or early balloon deflation, which would require medical monitoring and potentially early removal.

Ozempic presents a different profile of gastrointestinal side effects, including persistent nausea, diarrhea, and constipation, that can continue throughout treatment. Additionally, there are more serious, though rare, risks such as pancreatitis and gallbladder disease to consider, along with the ongoing need to monitor the long-term effects of continuous pharmaceutical intervention.

Side-by-side comparison table:

FeatureAllurion Gastric BalloonOzempic (Semaglutide)
Procedure & AdministrationNon-surgical, 15-minute placement (swallowed capsule); no endoscopy or sedation needed for placement or removal.Weekly self-administered subcutaneous injection.
Treatment DurationTemporary (16 weeks)Ongoing, often long-term or lifelong, to maintain results.
Average Weight Loss10–15% total body weight over 4 months.12–15% total body weight over 12–16 months.
Mechanism of ActionPhysical space occupation in the stomach to promote portion control.Hormonal action suppressing appetite and slowing gastric emptying.
Common Side EffectsInitial nausea, cramping, and reflux (typically subsides after the first week).Persistent nausea, diarrhea, constipation (can continue throughout use).
Potential ComplicationsEarly balloon deflation (rare)Pancreatitis, gallbladder disease, potential long-term unknowns.
Long-Term SustainabilityFocuses on building independent, healthy habits during the program.Results are contingent on continuous pharmaceutical intervention.
Cost StructureFixed, one-time program feeOngoing monthly prescription cost

Learn how Ozempic compares with surgical weight-loss options.

Why Choose the Allurion Gastric Balloon

The Allurion Balloon focuses on building sustainable habits rather than temporary suppression. Its 16-week program retrains your relationship with food through practical portion control and continuous coaching support. This approach creates lasting eating habits that remain long after the balloon passes naturally. You develop skills for lifelong weight management, not just short-term results.

Additionally, the gradual pace of weight loss provides important physiological benefits. By losing weight steadily over four months, your metabolism adapts more effectively than with rapid loss. This measured approach also gives your skin time to adjust gradually. You’re therefore less likely to experience significant loose skin compared to faster pharmaceutical methods.

Can I Combine Both Options?

Yes, the Allurion Balloon and Ozempic can be combined for a powerful, synergistic effect. While the balloon physically restricts food intake, Ozempic effectively manages the hunger and cravings that can occur during the initial adaptation period. This dual-action approach makes it significantly easier to adhere to a low-calorie diet, enhancing initial weight loss results.

Which Weight Loss Option Is Right for You

Choosing between a gastric balloon and Ozempic depends on your BMI, medical history, and weight-loss goals. While both options help with appetite control and portion reduction, they suit different types of patients.

Who Is a Good Candidate for a Gastric Balloon?

A gastric balloon is ideal for people who want a non-surgical, temporary tool to kick-start weight loss. Typical candidates include:

  • BMI between 27 and 35 (some programs accept up to BMI 40).
  • Individuals who haven’t achieved results through diet and exercise alone.
  • Patients who want structured coaching and a defined 4–6 month program.
  • People who prefer a non-surgical procedure with no incisions or anaesthesia.
  • Those not suitable for surgery or who want to avoid permanent anatomical changes.

A gastric balloon is not recommended for individuals with:

  • Prior major stomach surgery
  • Large hiatal hernia
  • Severe acid reflux
  • Certain gastrointestinal disorders

Who Is a Good Candidate for Ozempic?

Ideal candidates for ozempic include:

  • BMI ≥ 30, or
  • BMI ≥ 27 with a weight-related condition such as type 2 diabetes, high blood pressure and high cholesterol

Ozempic may also be considered for:

  • Individuals who cannot undergo bariatric surgery or prefer a medication-first approach
  • Patients needing gradual, medically supervised weight loss
  • People who benefit from appetite and craving control

Ozempic is not recommended for:

  • Pregnant or breastfeeding women
  • People with certain thyroid conditions
  • Individuals with a history of pancreatitis
  • Patients unable to commit to ongoing injections

When exploring your options for non-surgical weight-loss, gastric Botox presents another possibility. You can read more about its effects on weight loss in our detailed guide.

Frequently Asked Questions (FAQs)

What’s the difference between ozempic and gastric balloon

Ozempic is a pharmaceutical medications that work hormonally to suppress appetite, while gastric balloon is temporary medical device that physically occupy space in your stomach to promote portion control.

Which is safer, Ozempic or gastric balloon?

Both have excellent safety profiles when administered under medical supervision. The Allurion Balloon typically involves predictable, short-term side effects during adaptation, while Ozempic may cause persistent gastrointestinal issues and has rare but serious long-term risks that are still being studied.

Can you take Ozempic with gastric balloon?

Yes, this combination is increasingly used under medical supervision. Ozempic can effectively manage hunger during the balloon’s placement period, enhancing dietary adherence.

How long does it take to lose 5kg on Ozempic?

Most patients achieve 5kg weight loss within 2-3 months of consistent Ozempic use, though individual results vary based on starting weight, dosage, and lifestyle factors. The medication’s effects are gradual and cumulative.

What is Ozempic skin?

“Ozempic skin” refers to the loose or sagging skin that can result from rapid weight loss achieved through medications. The Allurion Balloon’s more gradual weight loss approach typically gives the skin a better opportunity to adapt, making this less likely to occur.

Is the Allurion balloon better than a traditional gastric balloon?

Yes, the Allurion Balloon offers significant advantages over traditional balloons. It requires no endoscopy for placement or removal, using instead a swallowable capsule. The balloon also self-removes after approximately 16 weeks, eliminating the need for a removal procedure.

Conclusion

Choosing between the Allurion Gastric Balloon and Ozempic hinges on your preference for a structured, temporary program versus a long-term pharmaceutical solution. stands out as a more powerful and transformative solution. It doesn’t just temporarily suppress your appetite, it physically retrains your body and mind for lasting change.

If you want to learn more about how the allurion balloon can help you achieve the weight loss you’re looking for, you can book a free consultation today to speak with our weight loss specialists. 

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